Basic information of Lrrc4 :
| Official Symbol of Gene | Lrrc4 |
| Species | Mus musculus |
| Entrez Gene ID | 192198 |
| Official Full Name | leucine rich repeat containing 4 |
| Also known as | NGL2; MBAG1; NGL-2; NLG-2; Nag14 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000049939 AllianceGenome:MGI:2182081 |
| Map Location | 6; 6 A3.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood /spinal cords |
| Sample Detail | NA |
| Detected Method | Immunohistochemistry/Western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 4 |
Literature information of multiple sclerosis :
| Pubmed ID | 33932995 |
| Year | 2021 |
| Title | LRRC4 functions as a neuron-protective role in experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We report that LRRC4 is mainly expressed in neuron of spinal cords, and is decreased in the spinal cords of the EAE mice. |
| Mechanism/Pathway | Leucine rich repeat containing 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), belongs to the superfamily of LRR proteins and serves as a receptor for netrin-G2. LRRC4 regulates the formation of excitatory synapses and promotes axon differentiation. Mutations in LRRC4 occur in Autism Spectrum Disorder (ASD) and intel-lectual disability. |
