Basic information of Mbp :
| Official Symbol of Gene | Mbp |
| Species | Mus musculus |
| Entrez Gene ID | 17196 |
| Official Full Name | myelin basic protein |
| Also known as | jve; mld; shi; Hmbpr; golli-mbp |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000041607 AllianceGenome:MGI:96925 |
| Map Location | 18 E3; 18 55.84 cM |
Sample information of multiple sclerosis:
| Detected Sample | lymph nodes |
| Sample Detail | NA |
| Detected Method | Immunohistochemistry |
| Disease | rEAE |
| Disease subtype | N/A |
| Population | SJL/J |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 9379062 |
| Year | 1997 |
| Title | Myelin Protein Expression I s Increased in Lymph Nodes of Mice with Relapsing Experimental Autoimmune Encephalomyeliti |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In all four models, expression of golli-MBP BG21 mRNA was increased two- to fivefold in lymph nodes of mice 45 to 60 days post-transfer. Immunohistochemical analysis indicated that expression occurred principally in macrophages within lymph nodes |
| Mechanism/Pathway | This larger gene encodes both the â€classic†MBPs as well as the structurally related golli-MBPs. In this study, golli-MBP expression in lymph nodes was examined in four different models of relapsing experimental autoimmune encephalomyelitis (rEAE). |
