Basic information of Creb1 :
| Official Symbol of Gene | Creb1 |
| Species | Homo sapiens |
| Entrez Gene ID | 12912 |
| Official Full Name | cAMP responsive element binding protein 1 |
| Also known as | Creb; Creb-1; 2310001E10Rik; 3526402H21Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000025958 AllianceGenome:MGI:88494 |
| Map Location | 1 C2; 1 32.74 cM |
Sample information of multiple sclerosis:
| Detected Sample | spinal cords |
| Sample Detail | NA |
| Detected Method | Immunohistochemistry/Western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Lewis rats |
| Sample Size | n= 5 rats/group |
Literature information of multiple sclerosis :
| Pubmed ID | 17617386 |
| Year | 2007 |
| Title | Increased phosphorylation of cyclic AMP response element-binding protein in the spinal cord of Lewis rats with experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Phenotypic risk |
| Result | Based on these results, we suggest that the increased phosphorylation of CREB in EAE lesions was mainly attributable to the infiltration of inflammatory cells and astrogliosis, possibly activating gene transcription,and that its increase in the sensory neurons in the dorsal horns is involved in the generation of neuropathic pain in the rat EAE model. |
| Mechanism/Pathway | To investigate whether the phosphorylation of cyclic AMP response element-binding p r o t e i n ( C R E B ) i s i m p l i c a t e d i n t h e p a t hogenesis of experimental autoimmune encephalomyelitis (EAE), the change in the level of CREB phosphorylation was analyzed in the spinal cord of Lewis rats with EAE. |
