Basic information of Cp :

Official Symbol of Gene	Cp
Species	Mus musculus
Entrez Gene ID	12870
Official Full Name	ceruloplasmin
Also known as	D3Ertd555e
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000003617 AllianceGenome:MGI:88476
Map Location	3; 3 A2

Sample information of multiple sclerosis:

Detected Sample	spinal cords
Sample Detail	NA
Detected Method	Immunohistochemistry/Western blot
Disease	EAE
Disease subtype	N/A
Population	C57BL/6
Sample Size	n = 10 mice

Literature information of multiple sclerosis :

Pubmed ID	24615902
Year	2014
Title	Ceruloplasmin gene-deficient mice with experimental autoimmune encephalomyelitis show attenuated early disease evolution

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Phenotypic risk
Result	. Based on these observations, we propose that an increase in Cp expression could contribute to tissue damage in early EAE. In addition, endogenous CP either directly or indirectly inhibits astrocyte reactivity during early disease, which could also worsen early disease evolution.
Mechanism/Pathway	Unexpectedly, ceruloplasmin (Cp), a ferroxidase that converts toxic ferrous iron to its nontoxic ferric form and also promotes the efflux of iron from astrocytes in the CNS, was shown to be highly upregulated (13.2-fold increase) in EAE spinal cord.