Basic information of Mt1 :
| Official Symbol of Gene | Mt1 |
| Species | Mus musculus |
| Entrez Gene ID | 17748 |
| Official Full Name | metallothionein 1 |
| Also known as | MT-I; Mt-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000031765 AllianceGenome:MGI:97171 |
| Map Location | 8 C5; 8 46.34 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain/liver |
| Sample Detail | NA |
| Detected Method | Immunohistochemistry |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Dark Agouti (DA)/ Albino Oxford (AO) |
| Sample Size | n = 5 |
Literature information of multiple sclerosis :
| Pubmed ID | 23485922 |
| Year | 2012 |
| Title | Metallothioneins I/II Expression in Rat Strains with Genetically Different Susceptibility to Experimental Autoimmune Encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Our data show that AO and DA rats differ in consti-tutive and inductive MT-I gene expression in the brain and in the liver, as well as in the hepatic cytokine profile, suggest-ing that these mechanisms may contribute to the discrep-ancy in the susceptibility to EAE |
| Mechanism/Pathway | Compared to the Dark Agouti (DA), the Albino Oxford (AO) rat strain exhibits lower susceptibility to the in-duction of experimental autoimmune encephalomyelitis (EAE). Here, we investigated the potential contribution of the heavy metal-binding proteins metallothioneins (MTs) I/II to these effects |
