Basic information of ATG16L2 :
| Official Symbol of Gene | ATG16L2 |
| Species | Homo sapiens |
| Entrez Gene ID | 89849 |
| Official Full Name | autophagy related 16 like 2 |
| Also known as | WDR80; ATG16B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168010 MIM:618716; AllianceGenome:HGNC:25464 |
| Map Location | 11q13.4 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | immunoblotting /bead fractionation/matrix-assisted laser desorption/ionizationtime-of-flight (MALDI-TOF) mass spectrometry analyses |
| Disease | MS |
| Disease subtype | NA |
| Population | NA |
| Sample Size | 54 MS/55Health |
Literature information of multiple sclerosis :
| Pubmed ID | 24406150 |
| Year | 2014 |
| Title | Autophagy-related gene16L2, a potential serum biomarker of multiple sclerosis evaluated by bead-based proteomic technology |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Eleven peptides were significantly different between the two groups with one being identified as a fragment of Atg16L2. |
| Mechanism/Pathway | The prolonged survival of autoreactive T cells acts as a primary event to trigger an inflammatory cascade that mediates myelin loss and clinical relapse in MS. |
