Basic information of Serpinb2 :
| Official Symbol of Gene | Serpinb2 |
| Species | Mus musculus |
| Entrez Gene ID | 18788 |
| Official Full Name | serine (or cysteine) peptidase inhibitor, clade B, member 2 |
| Also known as | PAI-2; Planh2; ovalbumin |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000062345 AllianceGenome:MGI:97609 |
| Map Location | 1 E2.1; 1 50.34 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain/spinal cords |
| Sample Detail | oligodendrocyte |
| Detected Method | immunofluorescence/Western blot/ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | n = 7mice |
Literature information of multiple sclerosis :
| Pubmed ID | 16342234 |
| Year | 2006 |
| Title | Induction of experimental autoimmune encephalomyelitis in transgenic mice expressing ovalbumin in oligodendrocytes |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Upon immunization with OVA in complete Freund's adjuvant, about half of the transgenic mice developed neurological symptoms characteristic of experimental autoimmune encephalomyelitis (EAE). |
| Mechanism/Pathway | We have used the 50 flanking sequence of the myelin basic protein gene known to include the core promoter and a strong oligodendrocyte (ODC)-specific enhancer to target expression of the well-studied model antigen ovalbumin (OVA) to ODC in transgenic mice. |
