Basic information of Ggt1 :
| Official Symbol of Gene | Ggt1 |
| Species | Mus musculus |
| Entrez Gene ID | 14598 |
| Official Full Name | gamma-glutamyltransferase 1 |
| Also known as | GGT; dwg; Ggtp; CD224; GGT 1; GGT-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000006345 AllianceGenome:MGI:95706 |
| Map Location | 10; 10 C1 |
Sample information of multiple sclerosis:
| Detected Sample | spinal cord |
| Sample Detail | N/A |
| Detected Method | immunohistochemistry and FACS |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 |
| Sample Size | 27 cases/4 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 32284594 |
| Year | 2020 |
| Title | Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | GGT was not detected in healthy spinal cord, but increased in microglia and infiltrating monocyte/macrophages in EAE lesions |
| Mechanism/Pathway | GGT degrades the antioxidant glutathione and its dysregulation interferes with redox homeostasis and oxidative stress responses |
