Basic information of B4GALT6 :
| Official Symbol of Gene | B4GALT6 |
| Species | Homo sapiens |
| Entrez Gene ID | 9331 |
| Official Full Name | beta-1,4-galactosyltransferase 6 |
| Also known as | B4Gal-T6; beta4Gal-T6 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000118276 MIM:604017; AllianceGenome:HGNC:929 |
| Map Location | 18q12.1 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | liquid chromotography and tandem mass spectrometry (LC-MS/MS) |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | lesions (n=10) / NAWM (n=5) / healthy controls (n=6) |
Literature information of multiple sclerosis :
| Pubmed ID | 25216636 |
| Year | 2014 |
| Title | Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We found increased expression of B4GALT5 (2.15±0.28 fold) and B4GALT6 (8.26±2.11 fold) in MS lesions, but not in normal appearing white matter (NAWM) or controls |
| Mechanism/Pathway | The increased expression of B4GALT5/6 was linked to increased LacCer levels in MS lesions |
