Basic information of Ccn2 :

Official Symbol of Gene	Ccn2
Species	Mus musculus
Entrez Gene ID	14219
Official Full Name	cellular communication network factor 2
Also known as	Ctgf; Hcs24; Fisp12; fisp-12
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000019997 AllianceGenome:MGI:95537
Map Location	10 A4; 10 11.84 cM

Sample information of multiple sclerosis:

Detected Sample	Spinal Cord
Sample Detail	morphology
Detected Method	Western blotting and immunocytochemistry
Disease	EAE
Disease subtype	N/A
Population	C57BL/6,RGC-32 KO mice
Sample Size	n = 11 areas per 4 mice in WT; n = 14 areas per 5 mice in RGC-32 KO. N: n = 13 areas per 4 mice in WT; n = 17 areas per 4 mice in RGC-32 KO. O: n = 8 areas per 3 mice in WT; n = 10 areas per 4 mice in RGC-32 KO

Literature information of multiple sclerosis :

Pubmed ID	33569054
Year	2021
Title	RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Expression	down-regulation
Risk type	disease risk
Result	In conclusion, our results clearly show that in the absence of RGC-32, CTGF levels remained lower in cultured astrocytes stimulated with TGF-β and in spinal cord astrocytes at the peak of EAE.
Mechanism/Pathway	We now show for the first time that RGC-32 acts upstream of CTGF in the TGF-β signaling pathway, and RGC-32-mediated regulation of CTGF expression is involved in ECM production.