Basic information of Gfap :

Official Symbol of Gene	Gfap
Species	Mus musculus
Entrez Gene ID	14580
Official Full Name	glial fibrillary acidic protein
Also known as	N/A
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020932 AllianceGenome:MGI:95697
Map Location	11 E1; 11 66.48 Cm

Sample information of multiple sclerosis:

Detected Sample	Spinal Cord
Sample Detail	morphology
Detected Method	Western blotting and immunocytochemistry
Disease	N/A
Disease subtype	N/A
Population	C57BL/6,RGC-32 KO mice
Sample Size	n = 11 areas per 4 mice in WT; n = 14 areas per 5 mice in RGC-32 KO. N: n = 13 areas per 4 mice in WT; n = 17 areas per 4 mice in RGC-32 KO. O: n = 8 areas per 3 mice in WT; n = 10 areas per 4 mice in RGC-32 KO

Literature information of multiple sclerosis :

Pubmed ID	33569054
Year	2021
Title	RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	disease risk
Result	Moreover, Western blot analysis demonstrated significantly higher levels of GFAP protein in WT astrocytes than in RGC-32 KO astrocytes (Figure 4C), whereas vimentin levels were higher in RGC-32 KO astrocytes (Figure 4D), paralleling the differences seen in vivo in the spinal cords.
Mechanism/Pathway	We now show for the first time that RGC-32 acts upstream of CTGF in the TGF-β signaling pathway, and RGC-32-mediated regulation of CTGF expression is involved in ECM production.