Basic information of SPP1 :
| Official Symbol of Gene | SPP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6696 |
| Official Full Name | secreted phosphoprotein 1 |
| Also known as | OPN; BNSP; BSPI; ETA-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000118785 MIM:166490; AllianceGenome:HGNC:11255 |
| Map Location | 4q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | plasma |
| Detected Method | Enzyme-linked Immunosorbent Assay |
| Disease | MS |
| Disease subtype | RRMS,SPMS,PPMS |
| Population | N/A |
| Sample Size | Thirty relapsing-remitting (RR), 10 secondary progressive(SP), and 10 primary progressive (PP) MS,10 healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 12783433 |
| Year | 2003 |
| Title | Elevated osteopontin levels in active relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In contrast, OPN protein levels in primary progressive and secondary progressive MS patients were similar to healthy control levels. Interestingly, active relapsing-remitting patients had higher OPN protein levels than patients without relapses |
| Mechanism/Pathway | These increased levels may contribute to a dysregulation of the Th1/Th2 balance as has been suggested by several studies. |
