Basic information of PDCD1 :
| Official Symbol of Gene | PDCD1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5133 |
| Official Full Name | programmed cell death 1 |
| Also known as | PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; Hsle1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000188389 MIM:600244; AllianceGenome:HGNC:8760 |
| Map Location | 2q37.3 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | CD8 T Cells |
| Detected Method | flow cytometry |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 45 patients with MS or clinically isolated syndrome and 12 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 35383094 |
| Year | 2022 |
| Title | Transcription Factor c-Maf Promotes Immunoregulation of Programmed Cell Death 1-Expressed CD8 T Cells in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | In the disease remission state, PD-1CD8 T cells were decreased in the peripheral blood of patients with MS and resolved in patients treated with IFN-β treatment who showed immune regulatory cytokine interleukin (IL)-10 expression. |
| Mechanism/Pathway | This study uncovered a favorable role of PD-1CD8 T cells against MS and demonstrated that c-Maf-driven IL-10 is an immune regulatory machinery. |
