Basic information of PTPN6 :
| Official Symbol of Gene | PTPN6 |
| Species | Homo sapiens |
| Entrez Gene ID | 5777 |
| Official Full Name | protein tyrosine phosphatase non-receptor type 6 |
| Also known as | HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111679 MIM:176883; AllianceGenome:HGNC:9658 |
| Map Location | 12p13.31 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | western immunoblot |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | normal subjects (n=32), untreated RR MS patients (n=30) |
Literature information of multiple sclerosis :
| Pubmed ID | 19559654 |
| Year | 2009 |
| Title | Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1 |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | As previously described, PBMCs of MS patients contained significantly lower levels of SHP-1 protein compared to normal subjects |
| Mechanism/Pathway | N/A |
