Basic information of OTUB1 :
| Official Symbol of Gene | OTUB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 55611 |
| Official Full Name | OTU deubiquitinase, ubiquitin aldehyde binding 1 |
| Also known as | OTB1; OTU1; HSPC263 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000167770 MIM:608337; AllianceGenome:HGNC:23077 |
| Map Location | 11q13.1 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | white matter |
| Detected Method | immunohistochemistry |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 10 MS cases |
Literature information of multiple sclerosis :
| Pubmed ID | 30944096 |
| Year | 2019 |
| Title | OTUB1 inhibits CNS autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Activated GFAP astrocytes in white matter MS lesions with inflammatory infiltrates and demyelination show an upregulation of OTUB1 (arrows). |
| Mechanism/Pathway | Mechanistically, OTUB1 inhibited IFN-γ-induced Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling by K48 deubiquitination and stabilization of the JAK2 inhibitor suppressor of cytokine signaling 1 (SOCS1). |
