Basic information of Slc8a3 :
| Official Symbol of Gene | Slc8a3 |
| Species | Mus musculus |
| Entrez Gene ID | 110893 |
| Official Full Name | solute carrier family 8 (sodium/calcium exchanger), member 3 |
| Also known as | Ncx3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000079055 AllianceGenome:MGI:107976 |
| Map Location | 12 D1; 12 37.44 Cm |
Sample information of multiple sclerosis:
| Detected Sample | spinal cord |
| Sample Detail | N/A |
| Detected Method | Western blotting and quantitative colocalization |
| Disease | EAE |
| Disease subtype | N/A |
| Population | Female wild-type ncx31/1 and knockout ncx32/2 mice |
| Sample Size | n=10 per group |
Literature information of multiple sclerosis :
| Pubmed ID | 27120265 |
| Year | 2016 |
| Title | Ncx3 gene ablation impairs oligodendrocyte precursor response and increases susceptibility to experimental autoimmune encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | NCX3 Protein Expression is Intensely Upregulatedin the Spinal Cord During the Chronic Stage of EAE |
| Mechanism/Pathway | Our findings demonstrate that knocking-out NCX3 impairs oligodendrocyte response and worsens clinical symptoms in EAE without altering the immune T-cell population. |
