Basic information of Bdkrb1 :

Official Symbol of Gene	Bdkrb1
Species	Mus musculus
Entrez Gene ID	12061
Official Full Name	bradykinin receptor, beta 1
Also known as	B1R; BKR1; B1BKR; Bdkrb; BRADYB1
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000041347 AllianceGenome:MGI:88144
Map Location	12; 12 E

Sample information of multiple sclerosis:

Detected Sample	spinal cord
Sample Detail	N/A
Detected Method	Western blot
Disease	EAE
Disease subtype	N/A
Population	female C57BL/6, kinin B1R127 knockout (B1R-/-) and kinin B2R-knockout (B2R-/-) mice
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	23454198
Year	2013
Title	The role of kinin B1 and B2 receptors in the persistent pain induced by experimental autoimmune encephalomyelitis (EAE) in mice: evidence for the involvement of astrocytes

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	B1R is over-expressed in the spinal cord of EAE mice
Mechanism/Pathway	The above data constitute convincing experimental evidence indicating that both kinin receptors, especially the B1 subtype, exert a critical role in the establishment of persistent hypersensitivity observed in the EAE model, an action that seems to involve a central inflammatory process, possibly acting on astrocytes.