Basic information of Tlr8 :
| Official Symbol of Gene | Tlr8 |
| Species | Mus musculus |
| Entrez Gene ID | 170744 |
| Official Full Name | toll-like receptor 8 |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000040522 AllianceGenome:MGI:2176887 |
| Map Location | X; X F5 |
Sample information of multiple sclerosis:
| Detected Sample | spinal cord |
| Sample Detail | N/A |
| Detected Method | Western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 23516559 |
| Year | 2013 |
| Title | 1,25-Dihydroxyvitamin D3 suppresses TLR8 expression and TLR8-mediated inflammatory responses in monocytes in vitro and experimental autoimmune encephalomyelitis in vivo |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Consistent with real-time PCR analysis of the TLR8 mRNA, we found that the abundance of the spinal cord cells expressing TLR8 protein was significantly increased in the EAE spinal cord and this increase was attenuated by 1,25(OH)2D3 treatment, as determined by immunostaining of the spinal cord sections with TLR8 antibody |
| Mechanism/Pathway | 1,25(OH)2D3 treatment not only significantly reduced TLR8 expression but also the expression or activity of MyD88, IRF-4, IRF-7 and NF-kB in monocytes challenged with TLR8 ligands. TLR8 promoter-luciferase reporter assays indicated that 1,25(OH)2D3 decreases TLR8 mRNA level in part via inhibiting TLR8 gene transcription activity. |
