Basic information of Il10 :
| Official Symbol of Gene | Il10 |
| Species | Mus musculus |
| Entrez Gene ID | 16153 |
| Official Full Name | interleukin 10 |
| Also known as | CSIF; If2a; Il-10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000016529 AllianceGenome:MGI:96537 |
| Map Location | 1 E4; 1 56.89 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | Western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 and MOG–T-cell receptor transgenic 2D2 mice |
| Sample Size | n = 10 |
Literature information of multiple sclerosis :
| Pubmed ID | 22411837 |
| Year | 2012 |
| Title | Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Significantly elevated levels of CCL2, IL-6, and CXCL10 protein were observed in the brain of LysMCre-SOCS3fl/fl mice compared with SOCS3fl/fl mice |
| Mechanism/Pathway | Thus, the absence of SOCS3 in myeloid cells causes enhanced STAT3 and STAT4 activation and elevated cytokine/chemokine expression in the brain. |
