Basic information of HPSE :
| Official Symbol of Gene | HPSE |
| Species | Rattus norvegicus |
| Entrez Gene ID | 64537 |
| Official Full Name | heparanase |
| Also known as | Hep; Hpa |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000002188 AllianceGenome:RGD:61969 |
| Map Location | 14p22 |
Sample information of multiple sclerosis:
| Detected Sample | spleen |
| Sample Detail | CD4 T cells |
| Detected Method | Western blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | rat |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 17656651 |
| Year | 2007 |
| Title | Expression of the heparan sulfate-degrading enzyme heparanase is induced in infiltrating CD4+ T cells in experimental autoimmune encephalomyelitis and regulated at the level of transcription by early growth response gene 1 |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | disease risk |
| Result | Regulation of heparanase expression in T cells and EAE |
| Mechanism/Pathway | The expression of Hpse in endothelial cells suggests that the enzyme may also contribute to the progression of disease in a non-T lymphocyte manner. |
