Basic information of Klrb1c :
| Official Symbol of Gene | Klrb1c |
| Species | Homo sapiens |
| Entrez Gene ID | 17059 |
| Official Full Name | killer cell lectin-like receptor subfamily B member 1C |
| Also known as | Nk1; Ly59; Nk-1; CD161; Ly-59; Ly55c; NK1.1; NKRP1; Nk1.2; Klrb1b; NK-RP1; Nk-1.2; Nkrp1b; Nkrp1c; ly-55c; NKRP140; NKR-P1.9 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000030325 AllianceGenome:MGI:107538 |
| Map Location | 6 F3; 6 63.09 cM |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | Flow cytometric analysis |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 43 patients, 47 healthy donors |
Literature information of multiple sclerosis :
| Pubmed ID | 21216829 |
| Year | 2011 |
| Title | CD161(high)CD8+T cells bear pathogenetic potential in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Flow cytometric analysis on peripheral blood of healthy donors and patients with multiple sclerosis and rheumatoid arthritis confirmed an upregulation of CD161 at the protein level, showing also a significant excess of CD161(high)CD8(+) T cells in multiple sclerosis. |
| Mechanism/Pathway | In summary, our work shows that CD161 expression on CD8 + T cells marks a subset of non-cytotoxic, proinflammatory, CCR6 + T lymphocytes that may play a role in multiple sclerosis immunopathogenesis by acting as effectors and targeting the CNS. |
