Basic information of Nr4a1 :
| Official Symbol of Gene | Nr4a1 |
| Species | Rattus norvegicus |
| Entrez Gene ID | 79240 |
| Official Full Name | nuclear receptor subfamily 4, group A, member 1 |
| Also known as | HMR; Nur77; Ngfi-b |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSRNOG00000007607 AllianceGenome:RGD:620029 |
| Map Location | 7q36 |
Sample information of multiple sclerosis:
| Detected Sample | spleen cells |
| Sample Detail | N/A |
| Detected Method | Western Blot |
| Disease | EAE |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 20079437 |
| Year | 2010 |
| Title | Microarray analysis identifies altered regulation of nuclear receptor family members in the pre-disease state of multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We further confirmed the findings by demonstrating low levels of NR4A1 protein in MS2b subjects, RRMS patients, and EAE rats. |
| Mechanism/Pathway | We conclude that the altered NR gene network apoptotic machinery prevents the extinction of activated T-cells and promotes the pathogenic process that will lead to the development of clinical disease. |
