Basic information of Sirt1 :
| Official Symbol of Gene | Sirt1 |
| Species | Mus musculus |
| Entrez Gene ID | 93759 |
| Official Full Name | sirtuin 1 |
| Also known as | Sir2; Sir2a; SIR2L1; Sir2alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000020063 AllianceGenome:MGI:2135607 |
| Map Location | 10; 10 B4 |
Sample information of multiple sclerosis:
| Detected Sample | retina |
| Sample Detail | N/A |
| Detected Method | immunofluorescence micrographs |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57Bl/6J |
| Sample Size | 16 |
Literature information of multiple sclerosis :
| Pubmed ID | 35740955 |
| Year | 2022 |
| Title | Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis |
Results of multiple sclerosis :
| Expression | N/A |
| Risk type | disease risk |
| Result | AAV7m8-Mediated Expression of SIRT1 in RGCs Reduces Demyelination but Not Inflammation in the EAE Mouse Model |
| Mechanism/Pathway | We conclude that despite minimally affecting the inflammatory response in the optic nerve, AAV7m8-mediated SIRT1 transfer into RGCs has a neuroprotective potential against RGC loss, axon demyelination and vison deficits associated with EAE. |
