Basic information of ACKR1 :
| Official Symbol of Gene | ACKR1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2532 |
| Official Full Name | atypical chemokine receptor 1 (Duffy blood group) |
| Also known as | FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1; DARC/ACKR1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000213088 MIM:613665; AllianceGenome:HGNC:4035 |
| Map Location | 1q23.2 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | Immunohistochemistry |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 3 MS and 3 control |
Literature information of multiple sclerosis :
| Pubmed ID | 36446612 |
| Year | 2023 |
| Title | Single-Cell Transcriptomics Identifies Brain Endothelium Inflammatory Networks in Experimental Autoimmune Encephalomyelitis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | disease risk |
| Result | We confirmed the elevated expression of ACKR1 (coding for the protein DARC, Figure 5, B and C) and LCN2 (coding for the protein lipocalin 2, Figure 5, B and D) on blood vessels in active MS lesions, compared with normal appearing white matter (NAWM) and with control brains. |
| Mechanism/Pathway | Venous ECs not only control immune cell trafficking through the expression of CAMs but can also act as immune stimulators or inhibitors through the expression of cell-specific cytokines/chemokines and receptors. |
