Basic information of NDI1 :
| Official Symbol of Gene | NDI1 |
| Species | Mus musculus |
| Entrez Gene ID | 854919 |
| Official Full Name | N/A |
| Also known as | N/A |
| Gene Type | protein coding |
| dbXrefs | AllianceGenome:SGD:S000004589 |
| Map Location | chromosome: XIII |
Sample information of multiple sclerosis:
| Detected Sample | retina |
| Sample Detail | N/A |
| Detected Method | Immunofluorescence,Western Blotting |
| Disease | EAE |
| Disease subtype | N/A |
| Population | DBA/1J mice |
| Sample Size | n = 20 |
Literature information of multiple sclerosis :
| Pubmed ID | 31900864 |
| Year | 2020 |
| Title | Gene Therapy with Single-Subunit Yeast NADH-Ubiquinone Oxidoreductase (NDI1) Improves the Visual Function in Experimental Autoimmune Encephalomyelitis (EAE) Mice Model of Multiple Sclerosis (MS) |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | disease risk |
| Result | In conclusion, targeting the dysfunctional complex I using NDI1 gene can be an approach to address axonal and neuronal loss responsible for permanent disability in MS that is unaltered by current disease modifying drugs. |
| Mechanism/Pathway | The 45% optic nerve axonal and 33% retinal ganglion cell (RGC) loss contributed to the permanent loss of visual function in EAE mice were ameliorated by NDI1-mediated prevention of mitochondrial cristae dissolution and improved mitochondrial homeostasis. |
