Basic information of Sort1 :
| Official Symbol of Gene | Sort1 |
| Species | Mus musculus |
| Entrez Gene ID | 20661 |
| Official Full Name | sortilin 1 |
| Also known as | Ntr3; Ntsr3; 2900053A11Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000068747 AllianceGenome:MGI:1338015 |
| Map Location | 3; 3 F3 |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | N/A |
| Detected Method | Western Blotting |
| Disease | EAE |
| Disease subtype | N/A |
| Population | DBA/1J mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 26566674 |
| Year | 2015 |
| Title | Role of Sortilin in Models of Autoimmune Neuroinflammation |
Results of multiple sclerosis :
| Expression | N/A |
| Risk type | disease risk |
| Result | Accordingly, sortilin was highly expressed by infiltrated perivascular myeloid cells, mainly in vessel cuffs, in the CNS of patients suffering from multiple sclerosis, the most common inflammatory autoimmune disease of the CNS. Yet, sortilin gene-targeted mice (Sort1(-/-)) and chimeras deficient in sortilin in the immune system were as susceptible as wild-type littermates to T cell-dependent experimental autoimmune encephalomyelitis. |
| Mechanism/Pathway | Considering our results and recent data from other investigators, we conclude that the proneurotrophin receptor sortilin plays a role in innate, rather than in adaptive, immune processes and, thus, not in autoimmune neuroinflammation. |
