Basic information of Nfatc1 :
| Official Symbol of Gene | Nfatc1 |
| Species | Mus musculus |
| Entrez Gene ID | 18018 |
| Official Full Name | nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 |
| Also known as | NFAT2; NFATc; NF-ATc; Nfatcb; 2210017P03Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000033016 AllianceGenome:MGI:102469 |
| Map Location | 18 E3; 18 53.66 cM |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | B cell |
| Detected Method | Western blots |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 21464221 |
| Year | 2011 |
| Title | NFATc1 affects mouse splenic B cell function by controlling the calcineurin– NFAT signaling network |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | NFATc1/ B cells suppress the synthesis of interferon-î§ by T cells in vitro, and these mice exhibit a mild clinical course of experimental autoimmune encephalomyelitis. In large part, the defective functions of NFATc1/ B cells are caused by decreased BCR-induced Ca2+ flux and calcineurin (Cn) activation. By affecting CD22, Rcan1, CnA, and NFATc1/î¡A expression, NFATc1 controls the Ca2+-dependent Cn–NFAT signaling network and, thereby, the fate of splenic B cells upon BCR stimulation |
| Mechanism/Pathway | NFATc1 ablation impaired Ig class switch to IgG3 induced by T cell–independent type II antigens, as well as IgG3+ plasmablast formation. Mice bearing NFATc1/ B cells harbor twofold more interleukin 10–producing B cells. |
