Basic information of TALDO1 :

Official Symbol of Gene	TALDO1
Species	Homo sapiens
Entrez Gene ID	6888
Official Full Name	transaldolase 1
Also known as	TAL; TALH; TAL-H; TALDOR
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000177156 MIM:602063; AllianceGenome:HGNC:11559
Map Location	11p15.5

Sample information of multiple sclerosis:

Detected Sample	Peripheral blood
Sample Detail	N/A
Detected Method	Western Blot Analysis
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	Patients included 95 with MS, 19 with Sjogren's syndrome (SJS), 25 with systemic lupus erythematous (SLE), and 32 with essential cryoglobulinemia (ECG)

Literature information of multiple sclerosis :

Pubmed ID	7964452
Year	1994
Title	Oligodendrocyte-specific Expression and Autoantigenicity of Transaldolase in Multiple Sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Presence of crossreactive antigenic epitopes between recombinant TAL-H and HTLV-I/human immunodeficiency virus type 1 (HIV-1) gag proteins was demonstrated by Western blot analysis. The results suggest that molecular mimicry between viral core proteins and TAL-H may play a role in breaking immunological tolerance and leading to a selective destruction of oligodendrocytes in MS
Mechanism/Pathway	TAL-H is a key enzyme of the nonoxidative pentose phosphate pathway (PPP) providing ribose-5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis