Basic information of Mog :
| Official Symbol of Gene | Mog |
| Species | Mus musculus |
| Entrez Gene ID | 17441 |
| Official Full Name | myelin oligodendrocyte glycoprotein |
| Also known as | B230317G11Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000076439 AllianceGenome:MGI:97435 |
| Map Location | 17 B1; 17 19.16 cM |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | Southern blotting |
| Disease | MS |
| Disease subtype | N/A |
| Population | C3H.SW and C57L mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 8898962 |
| Year | 1996 |
| Title | Delineation of the minimal encephalitogenic epitope within the immunodominant region of myelin oligodendrocyte glycoprotein: diverse V beta gene usage by T cells recognizing the core epitope encephalitogenic for T cell receptor V beta b and T cell receptor V beta a H-2b mice |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | the T cell reactivity against the immunodominant encephalitogenic region of MOG is characterized by a diverse Vp gene usage and a requirement for the same core epitope. This pattern of reactivity may favor epitope-directed, rather than TCR-targeted, approaches to immunospecific therapy for MOG-related autoimmune disease |
| Mechanism/Pathway | Encephalitogenic T cell lines from V(3†mice were also diverse in their TCR Vp gene usage (Vpl, Vp2, Vp6, Vp14 and Vp16). Such a heterogeneous TCR Vp gene expression by pMOG 35-55/I-Ab-reactive T cells from both Vpa and Vpb H-2b mice suggested multiple epitopes within pMOG 35-55. Analysis of the pattern of reactivity by pMOG 35-55-reactive T cells to a set of truncated peptides was not commensurate with independent nested epitopes, but revealed a requirement for recognition of a core sequence, YRSPFSRVV (pMOG 40-48) |
