Basic information of Lrp1 :
| Official Symbol of Gene | Lrp1 |
| Species | Mus musculus |
| Entrez Gene ID | 16971 |
| Official Full Name | low density lipoprotein receptor-related protein 1 |
| Also known as | Lrp; A2mr; CD91; b2b1554Clo |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000040249 AllianceGenome:MGI:96828 |
| Map Location | 10; 10 D3 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | Immunofluorescence |
| Disease | EAE |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 19299462 |
| Year | 2008 |
| Title | Low-density lipoprotein receptor-related protein 1 is an essential receptor for myelin phagocytosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In experimental autoimmune encephalomyelitis in mice, LRP1 protein expression was substantially increased in the cerebellum and spinal cord. LRP1 colocalized with multiple CNS cell types |
| Mechanism/Pathway | These studies establish LRP1 as a major receptor for phagocytosis of degraded myelin, which may function alone or in concert with co-receptors previously implicated in myelin phagocytosis |
