Basic information of Arid5a :
| Official Symbol of Gene | Arid5a |
| Species | Mus musculus |
| Entrez Gene ID | 214855 |
| Official Full Name | AT rich interactive domain 5A (MRF1-like) |
| Also known as | Mrf1; D430024K22Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000037447 AllianceGenome:MGI:2443039 |
| Map Location | 1; 1 B |
Sample information of multiple sclerosis:
| Detected Sample | Peritoneal macrophages |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | EAE |
| Disease subtype | N/A |
| Population | C57BL/6 wild-type mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 23676272 |
| Year | 2013 |
| Title | Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These results indicate that Arid5a plays an important role in promotion of inflammatory processes and autoimmune diseases. |
| Mechanism/Pathway | Arid5a was enhanced in macrophages in response to LPS, IL-1β, and IL-6. Arid5a deficiency inhibited elevation of IL-6 serum level in LPStreated mice and suppressed IL-6 levels and the development of TH17 cells in experimental autoimmune encephalomyelitis. Importantly, Arid5a inhibited the destabilizing effect of Regnase-1 on IL-6 mRNA |
