Basic information of TCF7L2 :
| Official Symbol of Gene | TCF7L2 |
| Species | Homo sapiens |
| Entrez Gene ID | 6934 |
| Official Full Name | transcription factor 7 like 2 |
| Also known as | TCF4; TCF-4 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000148737 MIM:602228; AllianceGenome:HGNC:11641 |
| Map Location | 10q25.2-q25.3 |
Sample information of multiple sclerosis:
| Detected Sample | Brainsã€spinal cords |
| Sample Detail | N/A |
| Detected Method | Immunohistochemistry |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57Bl/6 mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 23977356 |
| Year | 2013 |
| Title | Limited TCF7L2 Expression in MS Lesions |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | our data demonstrate that the expression of TCF7L2 in oligodendrocytes is limited to a certain differentiation stage; however the expression of TCF7L2 is neither restricted to the oligodendroglial lineage nor to (re-)myelinating conditions |
| Mechanism/Pathway | TCF7L2 binds to coeffectors such as β-catenin or histone deacetylases and thereby activates or inhibits the transcription of downstream genes involved in oligodendroglial differentiation |
