Basic information of TNFSF10 :

Official Symbol of Gene	TNFSF10
Species	Homo sapiens
Entrez Gene ID	8743
Official Full Name	TNF superfamily member 10
Also known as	TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000121858 MIM:603598; AllianceGenome:HGNC:11925
Map Location	3q26.31

Sample information of multiple sclerosis:

Detected Sample	venous blood
Sample Detail	N/A
Detected Method	ELISA
Disease	MS
Disease subtype	RRMS
Population	N/A
Sample Size	53 relapsing-remitting Egyptian MS patients and 25 matched healthy volunteers

Literature information of multiple sclerosis :

Pubmed ID	24913933
Year	2014
Title	Role of serum TRAIL level and TRAIL apoptosis gene expression in multiple sclerosis and relation to brain atrophy

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	No significant correlation was detected between the serum TRAIL level and the TRAIL mRNA expression ratio in either group. No statistically significant correlation was found between serum TRAIL levels or the TRAIL mRNA expression ratio with the number of black holes or the bicaudate ratio on MRI. Apoptosis of T lymphocytes is decreased in MS patients, which could be useful when designing treatments. There was no difference in the TRAIL mRNA gene expression ratio between MS patients and controls
Mechanism/Pathway	The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) molecule is among the potential biomarkers in MS