Basic information of Plp1 :
| Official Symbol of Gene | Plp1 |
| Species | Mus musculus |
| Entrez Gene ID | 18823 |
| Official Full Name | proteolipid protein (myelin) 1 |
| Also known as | jp; Plp; msd; rsh; DM20; jimpy |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623 |
| Map Location | X F1; X 59.1 cM |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | immunofluorescence |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6N |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 29970109 |
| Year | 2018 |
| Title | Teriflunomide attenuates neuroinflammation-related neural damage in mice carrying human PLP1 mutations |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Treatment of immune-incompetent PLP mutants did not provide evidence for a direct, neuroprotective effect of the medication. When treatment was terminated, no rebound of neuroinflammation occurred and histopathological improvement was preserved for at least 75 days without treatment. After disease onset, teriflunomide halted ongoing axonal perturbation and enabled a recovery of dendritic arborization by surviving ganglion cells. However, neither neuron loss nor clinical features were ameliorated, likely due to already advanced neurodegeneration before treatment onset. |
| Mechanism/Pathway | Preventive treatment with teriflunomide attenuated the increase in number of CD8+ cytotoxic effector T cells and fostered the proliferation of CD8+ CD122+ PD-1+ regulatory T cells in the CNS |
