Basic information of Prss57 :

Official Symbol of Gene	Prss57
Species	Mus musculus
Entrez Gene ID	73106
Official Full Name	protease, serine 57
Also known as	NSP4; Prssl1; UNQ782; GLGL782; 2900092M14Rik
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000020323 AllianceGenome:MGI:1920356
Map Location	10; 10 C1

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	Western blot analysis
Disease	MS
Disease subtype	N/A
Population	Female Wistar rats
Sample Size	n = 5–6 mice group

Literature information of multiple sclerosis :

Pubmed ID	32619071
Year	2019
Title	3p on multiple sclerosis through inhibiting PRSS57 and promotion of CD34+ cell proliferation in rats

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	miR‐134‐3p overexpression or PRSS57 silencing enhanced mitochondrial activity of neurons, mitochondrial membrane potential content, CD34+ cell proliferation, while decreasing Cyt C content, inflammatory response, and cell apoptosis. Collectively, overexpression of miR‐134‐3p promotes CD34+ cell proliferation via inhibition of PRSS57 in MS, which may serve as a promising target for MS intervention.
Mechanism/Pathway	analysis of the targeting relations of miR‐134‐3p and PRSS57 was conducted using online software and dual‐ luciferase reporter gene assay. Furthermore, neuronal functions, inflammatory response, proliferation, and apoptosis of CD34+ cells were assayed by flow cytometry, enzyme‐linked immunosorbent assay, and methyl thiazolyl tetrazolium. IL‐17 and PRSS57 expression increased while miR‐134‐3p expression decreased in the spinal cord from MS rats. miR‐134‐3p could target PRSS57