Basic information of Mag :
| Official Symbol of Gene | Mag |
| Species | Mus musculus |
| Entrez Gene ID | 17136 |
| Official Full Name | myelin-associated glycoprotein |
| Also known as | Gma; siglec-4a |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000036634 AllianceGenome:MGI:96912 |
| Map Location | 7 B1; 7 19.26 cM |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | Western blot |
| Disease | MS |
| Disease subtype | N/A |
| Population | female C57BL/6 mice |
| Sample Size | n =28 mice |
Literature information of multiple sclerosis :
| Pubmed ID | 36341924 |
| Year | 2023 |
| Title | Treadmill aerobic training improve beam-walking test, up-regulate expression of main proteins of myelin and myelination in the hippocampus of cuprizone-fed mice |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | performing aerobic exercise with CPZ consumption increased MBP gene expression and increased MAG and PLP protein expression, as well as increased myelination of nerve cells in the hippocampus compared to the CPZ group (p < 0.05). It seems that regular aerobic exercise in the MS model controls the destruction of myelin in the nerve cells of hippocampus by upregulating MBP, MAG and PLP, which can have positive effects on cognitive and motor performance |
| Mechanism/Pathway | Activation of T lymphocytes elicits an immune response against myelinforming cells, the oligodendrocytes. Oligodendrocytes, myelin sheath and white matter are the main targets of T lymphocytes that penetrate through the central nervous system. It has been stated that in CNS and PNS, MS causes the destruction of the myelin sheath around the axon in the brain and spinal cord, and impairs the ability of nerve cells in the brain and spinal cord to communicate with each other |
