Basic information of paddle :

Official Symbol of Gene	paddle
Species	Mus musculus
Entrez Gene ID	18462
Official Full Name	pad
Also known as	N/A
Gene Type	protein coding
dbXrefs	AllianceGenome:MGI:97469
Map Location	N/A

Sample information of multiple sclerosis:

Detected Sample	brain
Sample Detail	N/A
Detected Method	Northern blots
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	n = 5–6 mice group

Literature information of multiple sclerosis :

Pubmed ID	12064481
Year	2002
Title	Peptidylarginine deiminase: a candidate factor in demyelinating disease

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	From our data we concluded that up-regulation of myelin-associated PAD was responsible for the increase in citrullinated MBP in our transgenic mice prior to onset of clinical or pathological signs of demyelination. We postulate that a similar mechanism may be responsible for the increase in citrullinated MBP in multiple sclerosis
Mechanism/Pathway	Citrulline in proteins arises as a post-translational modification of arginine. In our original studies we isolated myelin basic protein (MBP) which contained six citrullinyl residues, two near the N terminal portion and four near the C-terminal portion of the molecule (Wood and Moscarello 1989) from normal human brain. This citrullinated MBP accounted for about 20% of the total MBP in normal, adult human brain