Basic information of NOS2 :
| Official Symbol of Gene | NOS2 |
| Species | Homo sapiens |
| Entrez Gene ID | 4843 |
| Official Full Name | nitric oxide synthase 2 |
| Also known as | NOS; INOS; NOS2A; HEP-NOS |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000007171 MIM:163730; AllianceGenome:HGNC:7873 |
| Map Location | 17q11.2 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | Astrocytes |
| Detected Method | Northern blots |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 15063753 |
| Year | 2004 |
| Title | Role of protein kinase R in double-stranded RNA-induced expression of nitric oxide synthase in human astroglia |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | This study delineates a novel role of dsRNA in inducing the expression of iNOS through dsRNAactivated protein kinase (PKR)-mediated activation of NF-UB and p38-mediated activation of C/EBPL in human astroglia that may participate in virus-induced neurological abnormalities |
| Mechanism/Pathway | This study underlines the importance of double-stranded RNA (dsRNA), the active component of a viral infection, in inducing the expression of inducible nitric oxide synthase (iNOS) in human astroglia. DsRNA in the form of synthetic polyinosinic-polycytidylic acid (poly IC) induced expression of iNOS and iNOS promoter-driven luciferase activity through activation of nuclear factor (NF)-UB and CCAAT/enhancer-binding proteinL (C/EBPL) |
