Basic information of Cd40 :
| Official Symbol of Gene | Cd40 |
| Species | Mus musculus |
| Entrez Gene ID | 21939 |
| Official Full Name | CD40 antigen |
| Also known as | IGM; p50; Bp50; GP39; IMD3; TRAP; HIGM1; T-BAM; Tnfrsf5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000017652 AllianceGenome:MGI:88336 |
| Map Location | 2 H3; 2 85.38 cM |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | Cells Primary microglia |
| Detected Method | Immunocytochemistry |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6J mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 16020513 |
| Year | 2016 |
| Title | LPS induces CD40 gene expression through the activation of NF-βB and STAT-1 in macrophages and microglia |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | LPS induces acetylation and phosphorylation of histones H3 and H4 and the recruitment of NF-rB, STAT-1, and RNA polymerase II on the CD40 promoter in vivo in a time-dependent manner, all events important for CD40 gene transcription. These results indicate that both LPS-induced NF-βB activation and endogenous production of IFN-r that subsequently induces STAT-1 activation play critical roles in the transcriptional activation of the CD40 gene by LPS. |
| Mechanism/Pathway | Blocking IFN-r–induced activation of STAT-1 by IFN-r–neutralizing antibody reduces LPS-induced CD40 gene expression |
