Basic information of Ndufa13 :
| Official Symbol of Gene | Ndufa13 |
| Species | Mus musculus |
| Entrez Gene ID | 67184 |
| Official Full Name | NADH:ubiquinone oxidoreductase subunit A13 |
| Also known as | CDA016; CGI-39; Grim19; GRIM-19; CI-B16.6; 2700054G14Rik |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000036199 AllianceGenome:MGI:1914434 |
| Map Location | 8; 8 B3.3 |
Sample information of multiple sclerosis:
| Detected Sample | spleens |
| Sample Detail | N/A |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6 mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 33163248 |
| Year | 2020 |
| Title | GRIM-19 Ameliorates Multiple Sclerosis in a Mouse Model of Experimental Autoimmune Encephalomyelitis with Reciprocal Regulation of IFNγ/Th1 and IL-17A/Th17 Cells |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The levels of Th1 and Th17 cells were measured via flow cytometry, immunofluorescence, and immunohistochemical analysis. IL-17A and IFNγ expression levels were assessed via ELISA and quantitative PCR. IL-17A expression decreased and IFNγ expression increased in EAE mice that received injections of the GRIM19 OVN. GRIM19 transgenic mice expressed more IFNγ than did wild-type mice; this inhibited EAE development. However, the effect of GRIM-19 overexpression on the EAE of IFNγ-KO mice did not differ from that of the empty vector. GRIM-19 expression was therapeutic for EAE mice, elevating the IFNγ level. GRIM-19 regulated the Th17/Treg cell balance |
| Mechanism/Pathway | The protein encoded by the Gene Associated with Retinoid-Interferon-Induced Mortality-19 (GRIM-19) is located in the mitochondrial inner membrane and is homologous to the NADH dehydrogenase 1-alpha subcomplex subunit 13 of the electron transport chain |
