Basic information of Plp1 :

Official Symbol of Gene	Plp1
Species	Mus musculus
Entrez Gene ID	18823
Official Full Name	proteolipid protein (myelin) 1
Also known as	jp; Plp; msd; rsh; DM20; jimpy
Gene Type	protein coding
dbXrefs	Ensembl:ENSMUSG00000031425 AllianceGenome:MGI:97623
Map Location	X F1; X 59.1 cM

Sample information of multiple sclerosis:

Detected Sample	spleens
Sample Detail	N/A
Detected Method	ELISA、Western blots
Disease	MS
Disease subtype	N/A
Population	Female BALB/c mice
Sample Size	n = 5–6 mice group

Literature information of multiple sclerosis :

Pubmed ID	16416423
Year	2006
Title	Monoclonal Antibodies to Distinct Regions of Human Myelin Proteolipid Protein Simultaneously Recognize Central Nervous System Myelin and Neurons of Many Vertebrate Species

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Widespread anti-PLP mAb recognition of neurons suggests a novel potential pathophysiologic mechanism in MS patients, i.e., that anti-PLP antibodies associated with demyelination might simultaneously recognize pgf epitopes in neurons, thereby affecting their functions
Mechanism/Pathway	In the present study, PLP knockout and wild-type mice were immunized with PLP and PLP peptides, and a large panel of monoclonal antibodies (mAbs) with reactivities to different PLP regions was generated. Selected mAbs were characterized for their reactivities to 1) whole PLP and PLP peptides by ELISA, 2) PLP and DM-20 on Western blots, and 3) live and fixed oligodendrocytes and normal human CNS tissue by immunohistochemistry. The results demonstrated the epitope specificity of the mAbs and their applicability to immunohistochemical studies of paraffin-embedded tissue samples