Basic information of Nfe2l2 :
| Official Symbol of Gene | Nfe2l2 |
| Species | Mus musculus |
| Entrez Gene ID | 18024 |
| Official Full Name | nuclear factor, erythroid derived 2, like 2 |
| Also known as | Nrf2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000015839 AllianceGenome:MGI:108420 |
| Map Location | 2 C3; 2 44.75 cM |
Sample information of multiple sclerosis:
| Detected Sample | Bone marrow mesenchymal stem cells |
| Sample Detail | N/A |
| Detected Method | Western Blot. |
| Disease | MS |
| Disease subtype | N/A |
| Population | C57BL/6J mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 31362266 |
| Year | 2021 |
| Title | Monomethylfumarate Protects against Ovariectomy-related Changes in Body Composition |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We demonstrated that MMF activated Nrf2 and induced anti-oxidant Nrf2 target gene expression in bone marrow-derived mesenchymal stem cells. |
| Mechanism/Pathway | The multiple sclerosis drug Tecfidera contains dimethylfumarate, which is rapidly metabolized to monomethylfumarate (MMF); MMF is thought to function through nuclear factor erythroid-derived-2-like-2 (Nrf2), a transcription factor activated by oxidative stress which induces the expression of endogenous antioxidant systems. We hypothesized that MMF-elicited increases in anti-oxidants would inhibit osteopenia induced by ovariectomy, as a model of aging-related osteoporosis and high oxidative stress |
