Basic information of Tnfaip3 :
| Official Symbol of Gene | Tnfaip3 |
| Species | Mus musculus |
| Entrez Gene ID | 21929 |
| Official Full Name | tumor necrosis factor, alpha-induced protein 3 |
| Also known as | A20; Tnfip3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000019850 AllianceGenome:MGI:1196377 |
| Map Location | 10 A3; 10 8.08 cM |
Sample information of multiple sclerosis:
| Detected Sample | corpus callosum and in the spinal cord |
| Sample Detail | microglial cells |
| Detected Method | Immunological Procedures |
| Disease | MS |
| Disease subtype | N/A |
| Population | TNFAIP3flox/flox mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 32325694 |
| Year | 2020 |
| Title | TNFAIP3 Deficiency Affects Monocytes, Monocytes-Derived Cells and Microglia in Mice |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The results suggest that TNFAIP3 in myeloid cells critically controls the development of M-MDC in lymphoid organ and of microglia in the CNS. |
| Mechanism/Pathway | The intracellular-ubiquitin-ending-enzyme tumor necrosis factor alpha-induced protein 3 (TNFAIP3) is a potent inhibitor of the pro-inflammatory nuclear factor kappa-light-chain-enhancer of activated B cell (NF-kB) pathway. |
