Basic information of P2rx4 :
| Official Symbol of Gene | P2rx4 |
| Species | Mus musculus |
| Entrez Gene ID | 18438 |
| Official Full Name | purinergic receptor P2X, ligand-gated ion channel 4 |
| Also known as | P2X4; D5Ertd444e |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000029470 AllianceGenome:MGI:1338859 |
| Map Location | 5 F; 5 62.53 cM |
Sample information of multiple sclerosis:
| Detected Sample | CSF |
| Sample Detail | N/A |
| Detected Method | Immunohistochemistry |
| Disease | NMOSD |
| Disease subtype | N/A |
| Population | Female Lewis rats |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 34419102 |
| Year | 2021 |
| Title | Anti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Conclusion We showed that AQP4-Ab promotes extracellular ATP release from astrocytes, and ATP-mediated neuropathic pain was suggested in NMOSD rat model. Our results indicate the critical role of ATP in the pathogenesis of AQP4-Ab–mediated pain development |
| Mechanism/Pathway | Development of mechanical allodynia was confirmed in rAQP4 IgG–treated rats. AQP4-Ab–mediated extracellular ATP release from astrocytes was observed in vitro, and pharmacological inhibition of ATP receptor reversed mechanical allodynia in the rAQP4 IgG–treated rats |
