Basic information of TF :

Official Symbol of Gene	TF
Species	Homo sapiens
Entrez Gene ID	7018
Official Full Name	transferrin
Also known as	TFQTL1; PRO1557; PRO2086; HEL-S-71p
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000091513 MIM:190000; AllianceGenome:HGNC:11740
Map Location	3q22.1

Sample information of multiple sclerosis:

Detected Sample	oligodendrocyte progenitors
Sample Detail	N/A
Detected Method	Immunofluorescence
Disease	MS
Disease subtype	N/A
Population	original hiPS cell
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	35743828
Year	2022
Title	Delayed Maturation of Oligodendrocyte Progenitors by Microgravity: Implications for Multiple Sclerosis and Space Flight

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	analysis of the secretome demonstrated that SPC-OLPs contained 3.5 times more Tf than that of GC cells, indicating that Tf is gravitationally regulated, opening two main fields of study to understand the upregulation of the Tf gene and secretion of the protein that keep OLPs at a progenitor stage rather than moving forward to more mature phenotypes. Alternatively, because Tf is an autocrine and paracrine factor in the central nervous system (CNS), in the absence of neurons, it accumulated in the secretome collected after space flight
Mechanism/Pathway	the iron carrier glycoprotein Tf, previously described as an early marker for OLPs, was expressed ectopically in the nucleus of all SPC-OLPs. In contrast, their GC counterparts expressed it exclusively in the cytoplasm, as previously described