Basic information of Cd86 :
| Official Symbol of Gene | Cd86 |
| Species | Mus musculus |
| Entrez Gene ID | 12524 |
| Official Full Name | CD86 antigen |
| Also known as | B7; B70; MB7; B7-2; B7.2; CLS1; Ly58; ETC-1; Ly-58; MB7-2; Cd28l2; TS/A-2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000022901 AllianceGenome:MGI:101773 |
| Map Location | 16 B3; 16 25.72 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | astrocyte |
| Detected Method | Immunocytochemical |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 9003248 |
| Year | 1997 |
| Title | Analysis of B7-1 and B7-2 costimulatory ligands in cultured mouse microglia: upregulation by interferon-g and lipopolysaccharide and downregulation by interleukin-10, prostaglandin E and cyclic 2 AMP-elevating agents |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | The above results indicate that local paracrine and autocrine mechanisms may be involved in a downregulatory loop that would inhibit B7 expression within the CNS and therefore reduce the potential for local antigen presentation. |
| Mechanism/Pathway | IFNg was a weak inducer of B7-2 mRNA and immunoreactivity in microglia primary cultures obtained from the neonatal mouse brain, whereas lipopolysaccharide, tumour necrosis factor-a, colony-stimulating factors and interleukin-1b did not affect microglial B7-2 expression |
