Basic information of Ifnb1 :
| Official Symbol of Gene | Ifnb1 |
| Species | Mus musculus |
| Entrez Gene ID | 15977 |
| Official Full Name | interferon beta 1, fibroblast |
| Also known as | Ifb; IFNB; If1da1; IFN-beta |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000048806 AllianceGenome:MGI:107657 |
| Map Location | 4 C4; 4 41.91 cM |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | immortalized fibroblasts |
| Detected Method | ELISA |
| Disease | MS |
| Disease subtype | N/A |
| Population | DBA/1 mice |
| Sample Size | N/A |
Literature information of multiple sclerosis :
| Pubmed ID | 9920019 |
| Year | 1999 |
| Title | AMELIORATION OF COLLAGEN-INDUCED ARTHRITIS AND SUPPRESSION OF INTERFERON-g, INTERLEUKIN-12, AND TUMOR NECROSIS FACTOR a PRODUCTION BY INTERFERON-b GENE THERAPY |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | These results indicate that IFNb, which is currently used as a treatment for relapsing, remitting multiple sclerosis, is a potent immunomodulatory and antiinflammatory cytokine in CIA and should be considered for the treatment of rheumatoid arthritis |
| Mechanism/Pathway | supernatants from these engineered fibroblasts inhibited collagen-induced interferon-g secretion from lymph node cells, and reduced the levels of tumor necrosis factor a and interleukin-12 produced by lipopolysaccharide/IFNg-treated bone marrow–derived macrophages. This effect was specific, since it was reversed with anti-IFNb polyclonal antibodies |
