Basic information of Tnf :
| Official Symbol of Gene | Tnf |
| Species | Mus musculus |
| Entrez Gene ID | 21926 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; Tnfa; TNF-a; TNFSF2; Tnlg1f; Tnfsf1a; TNFalpha; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000024401 AllianceGenome:MGI:104798 |
| Map Location | 17 B1; 17 18.59 cM |
Sample information of multiple sclerosis:
| Detected Sample | brain |
| Sample Detail | glioma cells and mouse brain cerebral cortical cells |
| Detected Method | electrophoretic mobility shift assays (EMSA) |
| Disease | ischemic or traumatic brain injury |
| Disease subtype | N/A |
| Population | Male BALB/c mice |
| Sample Size | 10 |
Literature information of multiple sclerosis :
| Pubmed ID | 11032280 |
| Year | 2000 |
| Title | Ketamine suppresses endotoxin-induced NF-6B expression |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Endotoxin treatment increased NF-6B expression (P < 0.05) both in vivo and vitro compared with control (untreated) cells. Ketamine suppressed endotoxin-induced neuronal NF-6B activation in a dose-dependent manner (P < 0.05, except for the 10–5M concentration in vitro) both in vivo and vitro |
| Mechanism/Pathway | whether ischemic or traumatic, results in an increase in brain cell neuronal NF-6B expression, which causes increased tissue concentrations of the proinflammatory cytokines, including IL-1 and TNF-a resulting in neuronal inflammation, injury, and cell death |
