Basic information of cysC :
| Official Symbol of Gene | cysC |
| Species | Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655) |
| Entrez Gene ID | 947221 |
| Official Full Name | adenylyl-sulfate kinase |
| Also known as | ECK2745 |
| Gene Type | protein coding |
| dbXrefs | ECOCYC:EG10185 |
| Map Location | NC_000913.3 (2873387..2873992, complement) |
Sample information of multiple sclerosis:
| Detected Sample | serum and CSF |
| Sample Detail | N/A |
| Detected Method | Immunoassay design |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 20cases/21controls |
Literature information of multiple sclerosis :
| Pubmed ID | 20202469 |
| Year | 2010 |
| Title | Development of an immunoassay for the detection of cystatin C dimers |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In CSF, the signal produced by the dimerized CysC was multifold compared to serum samples. Similar levels of total CysC and dimer were detected in both patient groups comprising of MS patients and patients with symptoms of the CNS, but confirmed not to have MS. The dimeric CysC assay could provide a valuable tool to explore CysC dimerization and oligomerization originating from body fluids or as conducted as a part of folding studies. |
| Mechanism/Pathway | The amyloid formation by a L68Q variant CysC accounts for the hereditary CysC amyloid angiopathy (HCCAA) |
