Basic information of Hdac1 :
| Official Symbol of Gene | Hdac1 |
| Species | Mus musculus |
| Entrez Gene ID | 433759 |
| Official Full Name | histone deacetylase 1 |
| Also known as | HD1; RPD3; MommeD5; Hdac1-ps |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000028800 AllianceGenome:MGI:108086 |
| Map Location | 4 D2.2; 4 63.26 cM |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | Western blot |
| Disease | MS |
| Disease subtype | N/A |
| Population | LM/Bc mice |
| Sample Size | n = 5–6 mice group |
Literature information of multiple sclerosis :
| Pubmed ID | 26719367 |
| Year | 2016 |
| Title | Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Elevated nuclear FTY720-P is associated with decreased HDAC activity and increased histone acetylation at H3K18 and H3K23 in LM/Bc MEFs. Treatment of LM/Bc MEFs with FTY720 and a selective Sphk2 inhibitor, ABC294640, significantly reduces the amount of FTY720-P that accumulates in the nucleus. The data provide insight into the relative amounts of FTY720-P generated in the nuclear versus cytoplasmic subcellular compartments after FTY720 treatment and the specific Sphk isoforms involved |
| Mechanism/Pathway | The results of this study suggest that FTY720-induced NTDs may involve multiple mechanisms, including: (1) sustained and/or altered S1P receptor activation and signaling by FTY720-P produced in the cytoplasm and (2) HDAC inhibition and histone hyperacetylation by FTY720-P generated in the nucleus that could lead to epigenetic changes in gene regulation |
